Diablo IV takes place following the aftermath of Diablo III: Reaper of Souls. Cultists have summoned the main antagonist and daughter of Mephisto, Lilith. After the events of previous games, the forces of demons and angels have been depleted, allowing an opening for her to establish power in Sanctuary.

In Diablo 4, ancient items are no more. Instead, Blizzard is opting for a system that will hopefully encourage more unique play styles. Players will earn a consumable that allows them to attach a Legendary affix to non-Legendary weapons, essentially creating your own ancient items.